Synthesis and biological evaluation of asymmetric gramicidin S analogues containing modified D-phenylalanine residues.

نویسندگان

  • Matthijs van der Knaap
  • Eefje Engels
  • Henk J Busscher
  • José M Otero
  • Antonio L Llamas-Saiz
  • Mark J van Raaij
  • Roos H Mars-Groenendijk
  • Daan Noort
  • Gijsbert A van der Marel
  • Herman S Overkleeft
  • Mark Overhand
چکیده

The synthesis of new analogues of the cationic antimicrobial peptide gramicidin S, having a modified D-phenylalanine residue, their antibacterial properties against several gram positive and negative strains, as well as their hemolytic activity is reported.

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عنوان ژورنال:
  • Bioorganic & medicinal chemistry

دوره 17 17  شماره 

صفحات  -

تاریخ انتشار 2009